Mónica Cristina García has completed 5 years degree at Universidad Nacional de Córdoba, Argentine. She is a pharmacist and she is working on her PhD thesis at the Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Particularly, she works in the Group of Pharmaceutical Technology led by Rubén H. Manzo, PhD. The goal of her work is to develop and study new pharmacotherapeutic systems, including novel drug delivery systems, in order to improve the efficacy and safety of Chagas disease treatment.
Hydrogels are usually defined as a crosslinked polymeric network having the capacity of holding large amount of water within its porous structure. Those comprise an important class of biomaterials specially used for drug delivery applications, due to their biocompatibility, good rheological and bioadhesive properties, high capacity of loaded drug and modified-release behaviors. This work reports the development of an antibacterial delivery system, under hydrogel form, based on a novel biocompatible dendronized polyelectrolyte (DP) as a carrier of ciprofloxacin (CIP). The ionic complexes of DP-CIP were formed by acid-base reaction using the high density of acid groups of the dendronized polymer and the amine groups of the ciprofloxacin drug. Hydrogels based on DP-CIP were easily prepared and showed excellent mechanical properties without dermal irritation for topical administration. A slow and diffusion-controlled in vitro release of CIP towards simulated physiological fluids was observed. The release performance could be attributed to the ion exchange phenomenon, revealing that the release of CIP from these hydrogels was appropriate, in terms of both magnitude and velocity. In vitro bacterial growth inhibition assay showed a significant CIP activity, corresponding to 38 and 58 % compared to that exhibited by CIP hydrochloride solution at similar CIP concentrations, against S. aureus and P. aeruginosa, respectively. In addition, the high biocompatibility of hydrogel was demonstrated by in vivo skin irritancy test. The hydrogel based on DP-CIP showed particularly promising properties that could be exploited for the treatment of topical and mucosal opportunistic infections in human or veterinary applications.
All university degrees obtained from the Cairo University Faculty of pharmacy. I published a set of research at a number of scientific journals. Participate in a number of international conferences in several universities in Egypt and Researcher centers also, participated in number of workshops. I participate as reviewer to several Pharmaceutical International Journals. Currently I am working as a Professor Pharmaceuticals Assistant at Taif University School of Pharmacy.
Zolmitriptan (Zl) is a selective serotonin receptor agonist. It is, used in the acute treatment of migraine attacks with or without aura and cluster headaches. It is affected by extensive first-pass effect (>60%) in addition concomitant food intake delays its absorption.rnrnAim: The purpose of this study is to formulate a buccal preparation of Zl as (buccal tablets and buccal hard gelatin capsule). They have been associated with numerous advantages over oral administration as avoidance of both hepatic and high bioavailability.rn rnMethods: A 23 full factorial design was adopted for the optimization of different formulae. The effects of the filler type, the binder molecular weight and of tablets, and capsules, and the effects of the disintegrant type (tablets) and the drying method (capsules) were studied. The prepared formulae were evaluated according to wetting properties and disintegration time using the new modified method. In vitro drug dissolution, permeation through the buccal mucosa and the effect of storage were analyzed by a new valid HPLC method. Bioavailability study was done on the best selected formulae.rnrnResults: Lyophilizations drying method and vacuum drying method are considered the best dying methods for preparation of buccal hard gelatin capsules. The disintegration times of tablets was lower than capsules time (from 36 to 178 sec). The presence of AC Di Sol as a disintegrant enhances the dissolution rate in tablets. In addition the formulations were found to be stable after twelve months at 25 °C and 75% RH.rnrnConclusion: The results revealed that buccal tablet formula of Bu would maintain rapid onset of action, and increased bioavailability.rn