Khalid Garba Mohammed
Bayero University, Nigeria
Title: Evaluation of filler/binder properties of modified starches derived from Plectranthus esculentus by direct compression in metronidazole tablets formulation
Biography
Biography: Khalid Garba Mohammed
Abstract
This study is aimed at evaluating the tableting properties of modified starches derived from Plectranthus esculentus as filler/binder by direct compression using metronidazole as a model drug, microcrystalline cellulose (MCC 101) was used as standard for comparison. Fresh tubers of P. esculentus were obtained from Bom area of Plateau state and starch extracted by wet milling. Three modifications of the starch were made, acid hydrolysis (APS), pregelatinization (PPS), and ethanol dehydrated pregelatinization (PPE). For drug-excipient compatibility studies, analytical technique Fourier Transform Infrared Spectroscopy (FTIR) was used. The drug and each of the excipients (1:1 w/w) were thoroughly mixed and analyzed. Powder and tableting properties of these modified starches were evaluated in comparison with microcrystalline cellulose (MCC 101). Powder characterization indicates that modified starches of P. esculentus have better flow properties because they have lower angle of repose (15.65 – 30.050) and higher flow rate (2.85 – 8.25 g/s) in comparison with MCC 101 with an angle of repose of 46.220 and flow rate of 0.80 g/s respectively. The FTIR results revealed no interaction of these excipients with the active drug. APS produced the best metronidazole tablets of better quality in terms crushing strength and friability and also drug-release profile with regards to disintegration and dissolution parameters compared to MCC 101 and other two modifications. Acid hydrolysis of P. esculentus starch therefore produced an excellent directly compressible filler/binder that can be substituted for MCC 101 in conventional tablet formulations.
