Luisa Fiandra
University of Milan, Italy
Title: Targeted inorganic nanodevices for breast cancer diagnosis and therapy
Biography
Biography: Luisa Fiandra
Abstract
Among the various kinds of tumors, breast cancer represents a target of primary interest, both from a diagnostic and a therapeutic point of view. In this context, powerful target-specific magnetic nanodevices can represent efficient contrast agent for MRI detection and good delivery system for anticancer drugs. Nowadays, many efforts are devoted to design nanosystems which can be localized at cancer cells for an extended period of time, in order to optimize diagnostic sensitivity and therapeutic efficiency. A valid example is represented by a versatile molecular superparamagnetic nanocomplex, functionalized with the commercial anti-human epidermal growth factor receptor 2 (HER2) trastuzumab (TZ) or TZ-derivatives. Several in vitro and in vivo experiments demonstrated the dependence of HER2 targeting efficiency from the structural features of the immobilized homing ligands. Moreover, the importance of precisely controlling the ligand density on the nanoparticle surface for optimizing active targeting and therapeutic effect was demonstrated. The best in vivo activity was obtained with monofunctionalized Tz- as compared with bifunctionalized Tz-nanoparticles.
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