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Achim Aigner


Achim Aigner

Leipzig University, Germany

Biography

Achim Aigner is Professor for Clinical Pharmacology with research interests in the (preclinical) development of novel therapeutic strategies based on small RNA molecules (siRNAs, miRNAs, antimiRs) in oncology. One major focus is on the development and evaluation of polymer-based nanoparticles for in vivo use, including chemical modifications. Systems are tested in various in vitro, ex vivo and in vivo models of solid tumors. To this end, different target genes (established and novel oncogenes) as well as tumor inhibitory miRNAs or the inhibition of oncogenic miRNAs are explored. 

Abstract

Abstract : Polymeric nanoparticles for therapeutic siRNA delivery: analysis of tissue-penetration and biological activities in tumor tissue slice cultures and in vivo xenograft models