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18th International Conference on Pharmaceutics & Novel Drug Delivery Systems, will be organized around the theme “Exploring The Unrevealed Sides of Novel Drug Delivery System”

Pharmaceutica Meet 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pharmaceutica Meet 2019

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It is defined as the method by which a drug is delivered can have a significant effect on its efficacy i.e. the drug become more efficacious in order to minimize drug degradation, drug adverse effect, and in order to increase the drug bioavailability to produce better therapeutic effect. NDDS covers various aspects like pharmacokinetics & pharmacodynamics, non-specific toxicity, immunogenicity, bio recognition, and drug’s efficacy based on preferable approaches that include polymer science, pharmaceutical technology, dispensing pharmacy, packaging technology, bio conjugate chemistry, and molecular biology. NDDS based on two mechanism i.e. physical and biochemical. Physical mechanism is like dissolution, osmosis, absorption, distribution, bioavailability, excretion and diffusion. Biochemical mechanism is like gene-protein therapy, liposomes-niosomes, Nano-micro particles, Monoclonal antibodies.

NDDS used to treat a wide range of severe disease by enhancing its performance in terms of patient compliance, safety and efficacy. Various drug delivery carriers & medical devices are used to enhance the NDDS through their target specific controlled action. Like – nanoparticles, Nano shell,  Nano tube, micro bubbles, micro sponges etc. They are administered to the body through a specific way reach the target site & release the medicaments incorporated in it after binding with the receptors in a controlled manner to show the better therapeutic effect.

  • Track 1-1Nanoparticles
  • Track 1-2Nano particulate drug delivery
  • Track 1-3Protein peptide drug carriers
  • Track 1-4Cancer cell targeting molecule
  • Track 1-5Microsphere
  • Track 1-6Carriers & vehicle

Pre-formulation studies are an important aspect for various stages of clinical trials & it is the the 1st stem in the formation of dosage form. Before formulation of the pharmaceutical product the pre-formulation studies are necessary. The main objective is to generate information useful to the formulation in developing physicochemically & biochemically stable & bioavailable dosage form. Various pre formulation study are – 1. Bulk Properties; 2. Polymorphism & Particle Size; 3. Hygroscopicity; 4. Aqueous Solubility; 4. Ionization Constant; 5. Partition Coefficient; 6. Drug Dissolution; 7. Drug Stability; 8. Drug Compatibility; 9. Half Life of drug; 10. Drug Absorption.

Through determination of physicochemical properties of inventing molecule, It states the steps of preparing drug delivery that enhance the drug performance & development of an efficacious, stable and safe dosage form. Nowadays the pre-formulation studies are become more accurate & comfortable with the help of statistical software based on artificial neural networking. These approaches accumulate the data regarding the degradation process, toxicological effects and adverse reaction. So Pre-formulation is a necessity in drug development & discovery.

 

  • Track 2-1Evaluation parameters in pre-formulation studies
  • Track 2-2Application of Analytical techniques in pre-formulation studies
  • Track 2-3Pre-formulation studies for generic products
  • Track 2-4Drug- excipient compatibility studies
  • Track 2-5Environment, health and safety considerations
  • Track 2-6Clinical Trials

In a simple word Pharmacokinetic is that what the body do with the drugs and reciprocally Pharmacodynamics is that what the drugs do with the body. Both are very common term of pharmacology. Pharmacokinetics consist of – 1. Absorption of the drug molecule by the body membrane; 2. Distribution of the drug to the organ and systemic circulation; 3. Metabolism of the drug molecule and attachment to the plasma membrane; 4. Excretion of the unused or excess drug or residue through urine or stool. The above 4 processes collectively called as ADME. Apart from that another one term is there that’s called bioavailability which is defined as the amount of drug available after absorption to work in the body and introduce into the systemic circulation.

Now the pharmacodynamics is includes – 1. Mechanism of Action – Specific biochemical interaction and reaction which the done with body to produce specific therapeutic effect;            2. Pharmacological Action – The therapeutic changes in the body due to the drug action;            3. Adverse Effect – The unusual effect of the drug differ from the desired pharmacological effect, which is a threat to the patient.

  • Track 3-1Therapeutic window & therapeutic index
  • Track 3-2Dose calculation
  • Track 3-3Toxic effect & drug interaction
  • Track 3-4Absorption, Distribution, Metabolism
  • Track 3-5Bioavailability & Excretion
  • Track 3-6Dose- response relationship

Drug delivery devices are mainly used reach the drug or medicaments to the site of action through a particular way. They are also employed to inject the drug though particular route on the basis of disease type, dosage form, target site etc. Those devices increase the activity of the drug delivery system by controlling time, dosage form, dose, and releasing site of the drugs & action site in the body. Target specificity, specific therapeutic effect, dose-optimization and   high degree of safety and efficiency are the distinctive features of these devices. Medical devices can be conventional or implantable.

Global drug delivery devices market is growing gradually due to increasing demand, advanced manufacturing technology, rising geriatric population and cancer patient. Some of the devices are Computed tomography scanning(CT), Magnetic resonance imaging(MRI), Ocular insert & Insulin jet, Implantable devices & Nebulizers. Medical devices prepared for pulmonary and nasal route are quite popular nowadays. These routes are intended for local delivery, as in asthma, but also for fast and accurate delivery of drugs to the systemic circulation and direct delivery to the CNS.

  • Track 4-1Magnetic resonance imaging(MRI)
  • Track 4-2Implantable devices
  • Track 4-3Pace makers and Defibrillators
  • Track 4-4X-ray generator
  • Track 4-5Instrumentation for medical use of radio isotopes & psychology measurements
  • Track 4-6Ocular insert & Insulin jet & Nebulizers
  • Track 4-7Computed tomography scanning(CT)

Route of administration is the path through which the drugs or any dosage form are administered into the body. The route of administration divided into – 1. The location at which the dosage form is applied, 2. The Target action. The routes of administration are very much important for the proper mechanism of action and therapeutic action of the drug. Selection of route mainly depends upon three factors – 1. The mechanism of action of the drug within the body, 2. Formula of the drug, 3. The treated part of the body.

Most of the novel formulation generally administered through the parenteral route like intravenous, intramuscular, subcutaneous, oral etc. to avoid the contamination and the drug degradation. If the drug is given through intravenous path then bioavailability should be 100 % & the therapeutic action will be lot better. Some drugs or formulation requires specific route for their administration to work perfectly in the body by trigger the specific receptor or site. Sometime also the route of administration is determined on the basis of site of action

  • Track 5-1Factors affecting the selection of route
  • Track 5-2Effects of route on drug discovery
  • Track 5-3Parenteral route
  • Track 5-4Transdermal route
  • Track 5-5Effects of route on therapeutic action of drug
  • Track 5-6Channels of drug administration

Targeted drug delivery is a type of intelligent drug delivery system. Mainly it is a mixture of sustained & controlled drug delivery system. This is a method of administering medication to a patient in a way that higher the level of concentration of the drug only in particular portion of the body. The drug after administration reaches the specific site of action, then they attach with the diseased tissue. The key driver of this drug delivery system is prolonged, slow, controlled but protected action of the drug towards the tissue for longer period of time to exhibit the proper & exact therapeutic effect & promote the treatment.

The supremacy of the targeted drug delivery is 1. Dosage frequency or dosage count reduction by the patient to avoid error. 2. Prolonged & uniform effect of the drug.  3. Decrease in side effect or adverse drug reaction. 4. Drug level fluctuation reduction i.e. uniform drug concentration. 5. Maintenance of the uniform plasma drug level due to controlled release. There are two types of targeted drug delivery- 1. Active targeted drug delivery that is antibody medications and 2. Passive targeted drug delivery such as the enhanced permeability and retention effect.

  • Track 6-1Various targeted site & receptors in the body
  • Track 6-2Cancer cell targeted drug delivery
  • Track 6-3Ideal characteristics
  • Track 6-4Strategies & application
  • Track 6-5Pro-drugs
  • Track 6-6Drug Delivery Vehicles

Nanotechnology drug delivery system  mainly improves and elevates the efficacy & action of any medicaments, creating new and better product. Nanoparticle brings revolutionary changes by simplifying the complex tissue culture through reconstruction. Hence the nanoparticle used to deliver the drugs particle or medicament to the specific site, receptors or disease cell. Then the drug particle attached to the specific receptors & attracted by the disease cell. After that they started working & provide treatment. The main advantage of nanotechnology is proper & specific action and less damage of the healthy tissue.

There are many types of nanotechnology dependent detectors and devices are available like nanotubes, nanowires, Nano probes Nano arrays, polymer nanoparticle, gold nanoparticle, magnetic nanoparticle, Nano capsule, Nano shell etc. Nanotechnology is the engineering of functional systems at the molecular level & manipulating matter at the Nano scale. Nano medicines are widely used in the cancer therapy. There are four types of nanotechnology based drug delivery systems – 1. Smart drug delivery systems, 2. Polymer–drug conjugates, 3. Multifunctional drug carriers, 4. Organic/inorganic composites.

  • Track 7-1Nanotechnology in medicine and drug delivery imaging
  • Track 7-2Nano drugs, Nanomaterial & biopharmaceuticals
  • Track 7-3Nanotechnology in cancer research & targeted drug delivery
  • Track 7-4Bio nanotechnology & pharmaceutical engineering
  • Track 7-5Nano mechanism of molecule
  • Track 7-6Clinical applications
  • Track 7-7Nanotechnology in industrial safety
  • Track 7-8Global investment & application

Nowadays, considerable attention has been focused on the development of novel drug delivery system for herbal drugs. There are various advantages of using herbal drugs like – No side effects, More Effectiveness, Lower cost & sufficient availability. Novel drug delivery overcomes the limitation of traditional drug delivery systems. We have a vast knowledge on Ayurveda but the techniques of administration we follow are out dated now. Combination of novel drug delivery technology & herbal medicine may help in increasing the therapeutic effect and decreasing the adverse effects of various herbal formulations. So it is important to integrate novel delivery system and Indian herbal medicines to combat many diseases.

Various types of formulation are used in the herbal novel drug delivery like- Liposomes, Niosomes, Phytosomes, Transferosomes, ethosomes & dendrimers. Reasons for using herbal medicines are - 1.  Increasing concern over the efficacy and safety of drugs 2. Failure of modern medicine to treat most common disease. 3. Herbal medicines are giving better results without less or no side effects.

  • Track 8-1Herbal remedies
  • Track 8-2Marketed herbal drug formulation
  • Track 8-3Recent research & developments & future prospects
  • Track 8-4Pharmaceutical aspects & clinical research of herbal drugs
  • Track 8-5Methodology
  • Track 8-6Nanoparticles in herbal formulation

A vaccine is a biological preparation that provides active adaptive immunity to a particular disease. Vaccine generally contains a component that is usually a disease-creating microorganism and is often made from weakened or killed forms of the microbe, pathogen, its toxins, or one of its surface proteins. There are many types of vaccine like – 1.Inactivated, 2.Attenuated, 3.Toxoid, 4.Subunit, 5.Conjugate, 6.Experimental, 7.Valance, 8.Heterotypic. The administration of the vaccine into the body is called vaccination which is the most effective method of preventing infectious disease.

Immunization system contains two types of doses That is – Prime dose & Booster dose. Immunization failed if the patient ignores the booster dose. Booster doses are required to induce a effective immunity. For that reason to skip the booster dose, invention of new generation prophylactic and therapeutic vaccine are required to initiate more effective immunization. Nowadays vaccine allows the incorporation of doses of antigen, that’s why antigen released in a very controlled way. Here the transportation of vaccine to the specific site are done by the carriers in a sustained release and accurate targeting manner.

  • Track 9-1Antigen dose incorporation to avoid booster dose
  • Track 9-2Therapeutic vaccination for auto immune diseases
  • Track 9-3Release of antigen in a controlled manner
  • Track 9-4Immune cell targeting
  • Track 9-5Influenza, cancer, HIV, HPV, Human vaccine & cancer vaccine
  • Track 9-6Novel & Veterinary vaccine
  • Track 9-7Clinical evaluation & market analysis
  • Track 9-8DNA delivery & pain free technology

Drug delivery is the procedure of administration of a pharmaceutical drug component into the body through various ways to get the pharmacological action of the drug. Drug delivery technologies transform the drug release profiles, pharmacokinetic and pharmacodynamics parameters to improve product efficacy and safety, as well as patient convenience and compliance. In the recent days the innovative & smart drug delivery technologies are very much important to reach the medicaments to proper site through proper way. Traditional & conventional drug delivery system failed in most cases in this scenario. So to deliver the protein, peptide, gene, vaccine, nanoparticles, antigen and some special form of drug – the innovative drug delivery technologies are essential to avoid the enzymatic degradation, acid degradation & some absorption and bioavailability related problems.

There are many technologies are involved like - needle-free drug delivery, transdermal drug delivery, fiber-based delivery for implantable devices, targeted penetration drug matrix technology for non-invasive drug delivery and location-specific Nano devices for chemotherapeutic medicine delivery. Not only that many other innovative technologies of novel drug delivery have been developed like-  implantable devices, Nano tubular drug delivery, protein peptide encapsulation, micro fabrication & chemical transformation.

  • Track 10-1Needle free technology
  • Track 10-2Microsphere drug delivery
  • Track 10-3Poorly soluble drug formulation
  • Track 10-4Jet injectors for vaccine delivery
  • Track 10-5Site or receptor specific delivery
  • Track 10-6Self-emulsifying drug delivery system
  • Track 10-7Particle size reduction IV-IV study

Nanoparticles are particulate dispersion with a size range of 10-1000 mm and consist of perishable materials like natural or synthetic polymer. The drugs are dissolved, dispersed & attached to the nanoparticle matrix. The nanoparticles are solid in nature & available in crystalline or amorphous form. Generally polymeric materials are used for the preparation of nanoparticles. In Nano capsule drugs are incorporated in a cavity surrounded by the polymeric membrane but in Nano sphere drug is uniformly shielded in polymer matrix system. Active targeting of the drugs at the specific site can be fulfilled by attachment of drug molecule with tissue or cell specific ligand but the passive targeting happened by the dispersion of the drugs in the polymer of Nano or Micro particle.

The key characteristics of the nanoparticles are - (1) improve the therapeutic activity and minimize adverse drug reactions associated with available drugs; (2) activate new classes of therapeutics; (3) Accelerate the re-invention of pharmaceutically ignored but biologically active new molecular substances that were previously underestimated. They are used in targeted drug delivery system to enhance the solubility of poorly soluble drug and also help in gene drug delivery.

  • Track 11-1Carbon Nanotubes
  • Track 11-2Dedrimers & Nano crystals
  • Track 11-3Gold Nano particles
  • Track 11-4Nano capsule & shell
  • Track 11-5Quantum dots
  • Track 11-6Nano pores, wires & cantilever
  • Track 11-7Polymer Nanoparticles

Drug designing also known as rational drug design. It is the research process of exploring new drugs or medications based on the study of a biological receptor target. The drug is an organic small molecule that accelerate or retardate the activity of a biomolecule such as a protein, peptide, gene etc. which results in the better therapeutic activity to the patient. Drug design discuss about the design & shape of drug molecules for perfect attachment to the targeting receptor or site to give the proper pharmacological effect. Drug designing often depends on the computer modeling technique which is called the computer aided drug designing (CADD). If the drug design depends upon the 3D bio molecular structural target i.e. called structure based drug designing. To a broad sense drug design is called ligand design because of tightly binding of drug molecule to its target.

Drug designing also improve the targeting of the drug molecule to the specific site or receptor and also tightening the binding of the molecule at the receptor binding site. Hence the therapeutic activity increases heavily.

  • Track 12-1Drug targeting strategies
  • Track 12-2Advances in drug targeting components
  • Track 12-3Rational & computer aided drug designing
  • Track 12-4Recent approaches to drug targeting
  • Track 12-5Factors influencing drug targeting

Controlled drug delivery is that type of system which release the medicaments from the dosage form at a predetermined specified rate for locally or systemically for a specified period of time. The main advantages of controlled drug delivery are – 1. Low amount of administered doses; 2. Less gastrointestinal side effects; 3. Less dosing frequency; 4. Improved patient acceptance & compliance; 5. Less ups & downs in plasma drug concentration; 6. Highly uniform drug action & effect; 7. Enhanced efficacy & drug safety.

The sustained release formulation is those which give slow but prolonged action. I.e. giving action for a long period of action without hampering the drug concentration.  Sustained release formulation maintains uniform drug plasma concentration. But the all type of medicaments cannot be administered through the sustained release drug delivery. Enteric coated tablet and capsule, implantable tablet are the example of this type of system. Reservoir type of mechanism is associated with this type of system.

  • Track 13-1Prolonged action
  • Track 13-2Enhancement of half-life of drug
  • Track 13-3Slow action
  • Track 13-4Poor dissolution rate
  • Track 13-5Site specific action
  • Track 13-6Enteric coated materials & Tablet hardness
  • Track 13-7Natural & Synthetic polymer

The aim of drug delivery systems is to deliver medications to specific site & receptors of the body through a medium using carrier, vehicle or medical devices that can control the therapy’s administration. To fulfill this aim, researchers are turning to advances in the worlds of micro technology and nanotechnology. Biological experts may be re-invented for blood bone barrier transport with the activity of molecular Trojan horse technology. Needle-free drug delivery technology is novel delivery ways to administered various medicines to the body for injecting powdered drugs into the skin.

Transdermal patches are user-friendly, convenient, cheap and painless and offer better patient compliance. Some Anti-cancer drugs such as loperamide and doxorubicin attached & dispersed to the polymer matrix of nanomaterial have been shown to cross the blood-brain barrier. The recent advances in the protein & gene peptide drug delivery systems are PEGylation and Depo-foam technology. The cell penetrating peptide shows their biological action through the transportation of hydrophilic macromolecules to the cell. New drug delivery technology include lipid, protein, gene, & polymeric technologies to produce new targeted drug delivery with better body distribution, drug protection, drug safety, better efficacy, patient compliance & therapeutic effect  from harsh external environment and avoidance of drug clearance.

  • Track 14-1In vitro drug release & novel degradable polymers
  • Track 14-2New Drug carrier systems
  • Track 14-3Immunoconjugates
  • Track 14-4Micro & Nano emulsion
  • Track 14-5Pulmonary & Mucosal drug delivery
  • Track 14-6Delivery through BBB
  • Track 14-7Implant devices & microchip technology

Currently North America has surpassed the entire continent in terms of novel drug delivery market in cancer research with a market share of around 38%. Due to excellent research & development in the field of drug delivery system, exceptional adoption rate of new technologies, helpful reimbursement policy – North America has surpassed all the continents in terms of market share. Europe also hold the 2nd position with a very respective market share of around 29% due to large number of cancer patient, development of clinical research facilities, awareness & the novel therapy to the cancer patient.

But Asia is the fastest growing novel delivery market & it shows a huge elevation in growth curve during recent times due to vast research activities, awareness, new therapy procedure, increased no. of cancer patient in china & japan. Currently in holds the 3rd position in global market with a share of around 20% but in future it is expected to boost the market growth. The total value of global NDDS market in 2016 was $4.31 Billion. The growth is boosted at a rate of 22.9% during recent period according to CGAR report.

Various novel pharmaceutical formulations are including the Nano medicine, transdermal patches, enteric coated tablets & capsule, implantable tablet, injectable intravenous & intramuscular preparation, micro bubbles & micro sponges, various Nano particles, microsphere etc.

  • Track 15-1North America dominates global injectable drug delivery market
  • Track 15-2Incremental & predicted drug device enhancement
  • Track 15-3Types & procedure of drug formulation
  • Track 15-4Vegetative formulation
  • Track 15-5Pharmaceutical equipment & drug release testing
  • Track 15-6Academy & industry perspective

In spite of invention of various new drugs, several challenges & problems are untouched and i.e. why compensation of our resources is necessary for the solving of the problem, development of new drugs, and new methods of treatment. Regulatory requirements and commitments have elevated heavily day by day and this lead to rise in both the trial size and the length and hence the overall cost of the development process becomes very high. The selection of the novel drug from a variety of solution is also a challenge and the development procedure is also very hectic. But current effort of development of drugs using innovative technologies becomes ineffective due to expensive clinical and preclinical data studies.

To overcome the challenges some steps can be taken like – 1. Cost efficient alternative development model can be prepared; 2. Innovation in the development procedure;                      3. Employment of more educated, experienced & technically abled specialist. Post marketing adverse drug reaction is also a major problem in this field i.e. why proper clinical research is required. The drug development model today is under a big threatened situation as the number of drugs approved for marketing has decreased to an all-time low. The developers are aware of this trend & try their best to overcome that.

 

  • Track 16-1Unpredictable biological mechanism of disease
  • Track 16-2Obstacles in new drugs approvals
  • Track 16-3Drug safety, adverse effect & patient compliance
  • Track 16-4Post marketing adverse drug reactions
  • Track 16-5Drug degradation
  • Track 16-6Genetic variations and implication in drug development
  • Track 16-7Manufacturing problems leading to drug shortages
  • Track 16-8Pharmacovigilance practices & clinical trials

In spite of having a huge freedom and advantages of NDDS, it also has some drawbacks and limitation. The administration and implementation cost of Nano medicine is much more expensive. Cytotoxicity of the nanoparticles also becomes a threat for future. Nano product facing greater problem due to their much higher cost and complexicity. The limited availability and lower production rate of personalized medicine & device is problematic for a large amount of user. Some innovative & noninvasive delivery improve the patient acceptance by lowering the marketed price & production cost. I.e. Why these results in the product degradation & quality issue.

Novel drugs which are administered through the oral cavity should possess the risk of undergoing acid or enzymatic degradation or hydrolysis. Some medical devices like Nano shell, Nano tube, Nano pores are difficult to administered into body of some patient, baby, or old people. All type of drugs or medicine cannot be administered  through the nanoparticles, carriers or devices because they cannot be incorporated in the polymer matric or they can be degraded. But the scientist and researchers are continuously try to overcome the drawbacks through their invention.

  • Track 17-1Barriers to drug delivery in tumors
  • Track 17-2 Challenges and barriers of ocular drug delivery
  • Track 17-3Formulation design of poorly soluble drugs
  • Track 17-4Vegetative formulation
  • Track 17-5Pharmaceutical equipment & drug release testing
  • Track 17-6Academy & industry perspective

There are a wide range of application of novel drug delivery system to the mankind includes -    1. Targeted & controlled drug delivery; 2. Faster action; 3. Used in the treatment of many severe disease like cancer; 4. Administration of those drugs which cannot be administered through the conventional drug delivery system; 5. Triggering of the target site, receptors or affected cell through the Nano particulate drug delivery; 6. Higher success rate; 7. Comparatively cheap but costly administration cost; 8. Delivery of protein peptide drugs; 9. Immune response study;      10. Transdermal drug delivery; 11. Fewer side effects.

Pharmaceutical innovations like the Novel Drug Delivery Systems present health professionals with a broad range of arsenals to treat diseases with never before efficacy, safety and precision. Clinically the NDDS not only smoothens the saw-tooth pattern of drug levels in blood, but also affords targeting the drugs to their site of action and thus reduces dose-related side effects. Smaller quantity of drug and fewer numbers of dosing could be used to treat a disease with increased success. It is hoped that with more and more research endeavors being focused into this arena, in near future, a large portions of the conventional dosage forms would be replaced by these NDDS and an overall betterment of health care delivery is expected with that change over. Pharmaceutical companies are interested to conduct research on NDDS to get edge over the big pharmaceutical companies to capture the regulated market through ANDA in regulated market. Moreover development and implementation of new branches like Pharmacovigilance will ensure availability of safer medicines to our people. Pharmacoeconomics will provide cost effective health care, which may help to extend the health care to the underprivileged.

 

  • Track 18-1Treatment of malignant tumor & cancer
  • Track 18-2Site specific therapeutic action
  • Track 18-3Clinical phase trial
  • Track 18-4Drug Safety & less side effect
  • Track 18-5Cheaper drug delivery
  • Track 18-6Spatial & temporal delivery
  • Track 18-7Specific & accurate treatment