Pharmacokinetic & Pharmacodynamics Study

In a simple word Pharmacokinetic is that what the body do with the drugs and reciprocally Pharmacodynamics is that what the drugs do with the body. Both are very common term of pharmacology. Pharmacokinetics consist of – 1. Absorption of the drug molecule by the body membrane; 2. Distribution of the drug to the organ and systemic circulation; 3. Metabolism of the drug molecule and attachment to the plasma membrane; 4. Excretion of the unused or excess drug or residue through urine or stool. The above 4 processes collectively called as ADME. Apart from that another one term is there that’s called bioavailability which is defined as the amount of drug available after absorption to work in the body and introduce into the systemic circulation.

Now the pharmacodynamics is includes – 1. Mechanism of Action – Specific biochemical interaction and reaction which the done with body to produce specific therapeutic effect;            2. Pharmacological Action – The therapeutic changes in the body due to the drug action;            3. Adverse Effect – The unusual effect of the drug differ from the desired pharmacological effect, which is a threat to the patient.

  • Therapeutic window & therapeutic index
  • Dose calculation
  • Toxic effect & drug interaction
  • Absorption, Distribution, Metabolism
  • Bioavailability & Excretion
  • Dose- response relationship

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