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16th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems, will be organized around the theme “Emerging Drug Delivery Technologies”
Pharmaceutica 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Pharmaceutica 2018
Submit your abstract to any of the mentioned tracks.
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Pharmaceutics is the study of relationships between preformulation, pharmaceutical formulation, delivery, disposition and clinical response. The inherent instability nature of a new drug will alter its desired form into undesired form when presented in a suitable dosage form with the excipient/s upon storage. In early days this process was confined only for assessing few characteristics, but today this process is being considered as a formulation strategy and hence tremendous technological advancement has been achieved in this field which enables us to save time and money through planned management system and hence impacts Pharmaceutica 2017 to be a formulation conference. Use of glorious statistical software even based on artificial neural networking are made the task of preformulation and optimization process easier. Role of preformulation studies techniques like freeze drying aspects projects the event Pharmaceutica 2017 to pose as a freeze drying meeting in drug discovery, drug development plays major role in pharmaceutical formulation development and the studies will help in different dosage forms design. With the increasing number of novel and specialized compounds being developed, a "one size fits all" approach to drug formulation and delivery is no longer optimal, necessitating the consideration of formulations unique to each drug. NDDS conference will discuss on Early Approaches, Present Scenario and Future Prospects of Preformulation events. There are more than 1400 sustained or controlled release drugs have been approved all over the world. Pharmaceutical conferences discuss the state-of-art technology being applied and involve advances in formulation studies.
Revenues within the global generics market reached an estimated value of $265 b in 2012, showing a growth of 9.3% throughout the year. The contribution of generics is approximately 20% of overall international pharmaceutical market. The utilization of generic in terms of volume is higher in the US and lower in Japan, 89% and 24% respectively.
- Track 1-1Preformulation in Drug Development
- Track 1-2Drug Formulation Considerations
- Track 1-3Major Challenges in Drug Development
- Track 1-4Physiological Drug Environment
- Track 1-5Freeze Drying
- Track 1-6Hot Melt Extrusion
The most fundamental goal in drug design is to predict whether a given molecule will bind to a target and if so how strongly. Molecular mechanics or molecular dynamics are most often used to predict the conformation of the small molecule and to model conformational changes in the biological target that may occur when the small molecule binds to it. The therapeutic response of a drug depends upon the interaction of drug molecules with cell on cell membrane related biological events at receptor sites in concentration dependent manner.
Selective and effective localization of the pharmacologically-active moiety at preidentified target(s) in therapeutic concentration, while restricting its access to non-target(s) normal cellular linings, thus minimizing toxic effects and maximizing the therapeutic index accounts from effective and efficient drug delivery.
Molecular mechanics methods may also be used to provide semi-quantitative prediction of the binding affinity. Also, knowledge-based scoring function may be used to provide binding affinity estimates. These methods use linear regression, machine learning, neural nets or other statistical techniques to derive predictive binding affinity equations by fitting experimental affinities to computationally derived interaction energies between the small molecule and the target.
- Track 3-1Factors influencing Drug Targeting
- Track 3-2Advances in Drug Targeting components
- Track 3-3Recent Approaches to Drug Targeting
- Track 3-4Rational Drug Design
- Track 3-5Computer Aided Drug Design
- Track 3-6Drug Design Theory
- Track 3-7Role of Computers in Drug Design: Their Success and Failure
- Track 3-8Rational Drug Design Software
- Track 3-9RACHEL Software Package
Nanoparticles (NPs) occur naturally and have been in existence for thousands of years as products of combustion and cooking of food. Nanomaterials differ significantly from other materials due to the following two major principal factors: the increased surface area and quantum effects. These factors can enhance properties such as reactivity, strength, electrical characteristics, and in vivo behaviour. As the particle size decreases, a greater proportion of atoms are found at the surface compared to inside. An NP has a much greater surface area per unit mass compared with larger particles, leading to greater reactivity. In tandem with surface area effects, quantum effects can begin to dominate the properties of matter as size is reduced to the nanoscale. These can affect the optical, electrical, and magnetic behaviour of materials. Their in vivo behaviour can be from increased absorption to high toxicity of nanomaterials. New drug carrier systems are one can name soluble polymers, microparticles made of insoluble (or) biodegradable natural and synthetic polymers, microcapsules, cells, cell ghosts, lipoproteins, liposomes and micelles. Pharmaceutica 2017 evolves to be a drug disintegration conference, emulsion conference, capsule conference, and solubility conference. Pharmaceutical conferences will cover industry case studies, regulatory updates, latest therapies and technology innovations and much more.
Key players in the market include Amgen, Inc., AstraZeneca plc, Eli Lilly & Co., Ipsen S.A., Merck & Co., Novartis AG, Novo Nordisk A/S, Roche Holdings AG, Sanofi, Takeda Pharmaceutical Company Limited, and Teva Pharmaceutical Industries Limited. Leading API manufacturers include Bachem Holding AG, PolyPeptide Group, and Peptisyntha Inc. at the pharmaceutical companies’ conference.
The global market for blood-brain barrier (BBB) technology for therapeutics reached $21.8 million in 2013. This market is expected to grow from $38.7 million in 2014 to $471.5 million in 2019, a compound annual growth rate (CAGR) of 64.9% from 2014 through 2019.
- Track 5-1Liposomal Drug Delivery Systems
- Track 5-2Nanogels
- Track 5-3Cyclodextrins
- Track 5-4Micelles
- Track 5-5Dendrimers
- Track 5-6Organic Nanotubes: Promising Vehicles for Drug Delivery
- Track 5-7Polymers
- Track 5-8Solid Lipid Nano and Microparticles
- Track 5-9Microemulsions and Nanoemulsions
- Track 5-10Metal Nanoparticles and Quantum Dots
Size reduction is a fundamental unit operation having important applications in pharmacy. It helps in improving solubility and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drugs. In most of the cases, size reduction is limited to micron size range, for example, various pharmaceutical dosage forms like powder, emulsion, suspension etc. Drugs in the nanometer size range enhance performance in a variety of dosage forms. Major advantages of nanosizing include (i) increased surface area, (ii) enhanced solubility, (iii) increased rate of dissolution, (iv) increased oral bioavailability, (v) more rapid onset of therapeutic action, (vi) less amount of dose required, (vii) decreased fed/fasted variability, and (viii) decreased patient-to-patient variability.
Pharmaceutical nanotechnology has provided more fine-tuned diagnosis and focused treatment of disease at a molecular level. Pharmaceutical nanotechnology is most innovative and highly specialized field, which will revolutionize the pharmaceutical industry in near future. Pharmaceutical nanotechnology presents revolutionary opportunities to fight against many diseases. It helps in detecting the antigen associated with diseases such as cancer, diabetes mellitus, neurodegenerative diseases, as well as detecting the microorganisms and viruses associated with infections. It is expected that in next 10 years market will be flooded with nanotechnology devised medicine.
- Track 7-1Pharmaceutical Nanotechnology based Systems
- Track 7-2Characterization of Pharmaceutical Nanotools
- Track 7-3Engineering of Pharmaceutical Nanosystems
- Track 7-4Applications of Pharmaceutical Nanotools
- Track 7-5Challenges to Pharmaceutical Nanotechnology
- Track 7-6Future Prospects of Pharmaceutical Nanotechnology
- Track 7-7Overcoming addictive nature of drugs
- Track 7-8Advances in self-emulsifying drug delivery systems (SEDDS)
Smart drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others. This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue. The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue. The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels. The disadvantage of the system is high cost, which makes productivity more difficult and the reduced ability to adjust the dosages.
Targeted drug delivery systems have been developed to optimize regenerative techniques. The system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. This helps maintain the required plasma and tissue drug levels in the body, thereby preventing any damage to the healthy tissue via the drug. The drug delivery system is highly integrated and requires various disciplines, such as chemists, biologists, and engineers, to join forces to optimize this system.
The global revenue for advanced drug delivery systems is estimated to be $151.3 billion in 2013. In 2018, revenues are estimated to reach nearly $173.8 billion, demonstrating a compound annual growth rate (CAGR) of 2.8%.
- Track 9-1Targeted Drug Delivery
- Track 9-2Nucleic Acid Drug Delivery Systems
- Track 9-3Antibody Targeted-Drug Conjugates
- Track 9-4Blood Brain Barrier Delivery
- Track 9-5BioMEMS
- Track 9-62D and 3D Printing In Drug Delivery
- Track 9-7Self-Emulsifying Drug Delivery Systems (SEDDS)
- Track 9-8Insulin Delivery
- Track 9-9Cancer Delivery
- Track 9-10Pulmonary Drug Delivery
- Track 9-11Skin Drug Delivery
- Track 9-12Mucosal Drug Delivery
- Track 9-13Proteins and Surfaces
- Track 9-14Gene Delivery
Biomaterials are any substance that has been engineered to interact with biological systems for a medical purpose - either a therapeutic (treat, augment, repair or replace a tissue function of the body) or a diagnostic one. Biomaterials can be derived either from nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers, ceramics or composite materials. They are often used and/or adapted for a medical application, and thus comprise whole or part of a living structure or biomedical device which performs, augments, or replaces a natural function. Such functions may be benign, like being used for a heart valve, or may be bioactive with a more interactive functionality such as hydroxy-apatite coated hip implants. Biomaterials are also used every day in dental applications, surgery, and drug delivery. For example, a construct with impregnated pharmaceutical products can be placed into the body, which permits the prolonged release of a drug over an extended period of time. A biomaterial may also be an autograft, allograft or xenograft used as a transplant material. Pharmaceutica 2017 have penetrated into the biomaterials realm and hence a biomaterials conference.
Global revenue for vaccine technologies was nearly $31.8 billion in 2011. This market is expected to increase from $33.6 billion in 2012 to $43.4 billion in 2017 at a compound annual growth rate (CAGR) of 5.3%.
- Track 10-1Cells and Proteins
- Track 10-2Nanomaterials & Nanotechnologies
- Track 10-3Musculoskeletal
- Track 10-4Biomaterials & Therapeutics
- Track 10-53D Printing Technologies
- Track 10-6Biomaterials Processing & Devices
- Track 10-7Translational Sciences
- Track 10-8Wound Healing
- Track 10-9Polymers
- Track 10-10Ceramics and Metals
- Track 10-11Proteins and Surfaces
- Track 10-12Tissue Regeneration
Vaccine is a material that induces an immunologically mediated resistance to a disease but not necessarily an infection. Vaccines are generally composed of killed or attenuated organisms or subunits of organisms or DNA encoding antigenic proteins of pathogens. Sub-unit vaccines though exceptionally selective and specific in reacting with antibodies often fail to show such reactions in circumstances such as shifts in epitopic identification center of antibody and are poorly immunogenic. Delivery of antigens from oil-based adjuvants such as Freunds adjuvant lead to a reduction in the number of doses of vaccine to be administered but due to toxicity concerns like inductions of granulomas at the injection site, such adjuvants are not widely used. FDA approved adjuvants for human uses are aluminium hydroxide and aluminium phosphate in the form of alum. Hence, search for safer and potent adjuvants resulted in the formulation of antigen into delivery systems that administer antigen in particulate form rather than solution form.
Other reasons driving the development of vaccines as controlled drug delivery systems are as follows:
· Immunization failure with conventional immunization regimen involving prime doses and booster doses, as patients neglect the latter. Vaccines delivery systems on the other hand:
· Allow for the incorporation of doses of antigens so that booster doses are no longer necessary as antigens are released slowly in a controlled manner.
· Control the spatial and temporal presentation of antigens to the immune system there by promoting their targeting straight to the immune cells.
The global market for pharmaceutical and biopharmaceutical contract manufacturing, research and packaging was $219.9 billion in 2012. This market is estimated to reach $242.2 billion in 2013 and $374.8 billion by 2018, a five-year compound annual growth rate (CAGR) of 9.1%.
- Track 11-1Cancer vaccines
- Track 11-2New vaccines
- Track 11-3Therapeutic vaccination for auto immune diseases
- Track 11-4HPV vaccines
- Track 11-5HIV/AIDS vaccines
- Track 11-6Human vaccines
- Track 11-7Clinical trials
- Track 11-8Novel vaccines
- Track 11-9Influenza vaccines/virus
- Track 11-10Veterinary vaccines
A medical device is any instrument, apparatus, appliance, software, material or other article, whether used alone or in combination, including the software intended by its manufacturer to be used specifically for diagnostic and/or therapeutic purposes and necessary for its proper application, intended by the manufacturer to be used for human beings for the purpose of:
· Diagnosis, prevention, monitoring, treatment or alleviation of disease;
· Diagnosis, monitoring, treatment, alleviation of or compensation for an injury or handicap;
· Investigation, replacement or modification of the anatomy or of a physiological process;
Medical devices vary according to their intended use and indications. Examples range from simple devices such as tongue depressors, medical thermometers, and disposable gloves to advanced devices such as computers which assist in the conduct of medical testing, implants, and prostheses. The design of medical devices constitutes a major segment of the field of mechanical engineering. Pharmaceutica 2017 is considered to be a medical devices conference.
The drug-device combination market is not fragmented and the key players in this market are Medtronic, Boston Scientific Corp., Edwards Life sciences Corp., Stryker Corp., QLT Inc. etc. The maximum number of new product developments is expected to take place in the bone graft substitutes, advanced wound care products and antimicrobial catheter markets. Our patent analysis indicates that E.U. has filed for the maximum number of patents followed by the U.S.
- Track 12-1Magnetic Resonance Imaging
- Track 12-2Computed Tomographic Scanning (CT Scanning)
- Track 12-3Ultrasonography
- Track 12-4Ophthalmic and ENT Instruments
- Track 12-5Instrumentation for the Medical Use of Radioisotopes
- Track 12-6Quality by Design (QbD)
- Track 12-7Pacemakers and Defibrillators
- Track 12-8Respiratory Therapy Equipment
- Track 12-9Instrumentation for the Experimental Analysis of Behaviour
- Track 12-10Instrumentation for Psychophysiological Measurements
- Track 12-11Measurement of Blood Flow and Cardiac Output
- Track 12-12Biomedical Instrumentation Measurements
- Track 12-13Positron-Emission Tomographic (PET) Scanning
Peptides and proteins have great potential as therapeutics. Peptides can be designed to target a broad range of molecules, giving them almost limitless possibilities in fields such as oncology, immunology, infectious disease and endocrinology. While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Although oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract. Therefore, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to facilitate oral peptide delivery. Additionally, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonization and agglutination, free peptides are not systemically stable without modifications.
Currently, the market for peptide and protein drugs is estimated to be greater than US$40 billion/year, or 10% of the pharmaceutical market. This market is growing much faster than that of small molecules, and will make up an even larger proportion of the market in the future. At present there are over 100 approved peptide-based therapeutic drugs on the market, with the majority being smaller than 20 amino acids. Compared with the typical small-molecule drugs that currently make up the majority of the pharmaceutical market, peptides and proteins can be highly selective as they have multiple points of contact with their target. Increased selectivity may also result in decreased side effects and toxicity.
Major drugs driving growth of the overall smart drug delivery market include Angiomax, Copaxone, Forteo, Sandostatin, Velcade, Victoza and Zoladex.
- Track 13-1Peptide Vector for Biologics Brain Delivery
- Track 13-2Protein Formulation & Aggregation
- Track 13-3Protein therapeutics
- Track 13-4Polymers for delivery of proteins
- Track 13-5Peptide therapeutics
- Track 13-6Cell-penetrating and cell-targeting