Nawal Khalafallah
Alexandria University, Egypt
Title: Challenges facing liposomal delivery of Vancomycin for combating bacterial biofilm on abiotic surfaces
Biography
Biography: Nawal Khalafallah
Abstract
Several published articles have tackled the issue of improving vancomycin performance. Th e performance areas targeted in these studies included broadening antibacterial spectrum to include Gram-negative organisms, enhancing antibacterial activity against drug resistant Staphylococcus aureus and enhancing the antibiofi lm activity. One of the active research areas in the Department of Pharmaceutics has been lipid vesicles including liposomes and niosomes among other types of modifi ed liposomes such as propylene glycol liposomes with the aim of using these vesicles as vancomycin carriers to improve antibiofi lm activity including inhibition and eradication of biofi lms forming on abiotic sufaces such as catheters. Th is presentation focuses on challenges encountered, and on lessons learnt, while conducting research in this area. Some of the challenges are related to vancomycin itself and some arise from the methodology used. Th e presentation also touches on speculation of how to move such systems from bench to bedside.
