B B Barik
Jazan University, Kingdom of Saudi Arabia
Title: Chitosan nanoparticles - Challenges for antibiotic drug delivery using Penicillin as a model drug
Biography
Biography: B B Barik
Abstract
Antibiotic resistance is one of the major health problems worldwide. Resistance to penicillin is well recognized in Staphylococcus aureus and Staphylococcus epidermidis. During last decade various resistance mechanisms such as decreased uptake, increased effl ux of drug from bacterial cell, formation of biofi lms to avoid contact with antibiotics have been identifi ed that lead to failure in the treatment. Th e concept of drug delivery system is rapidly moving towards the development of biodegradable polymeric nanoparticles. For past two decades many researchers have been developing nanoparticle drug delivery especially delivering of anticancer drugs and vaccines. Th e main advantage of this system is to deliver drug moiety at the site of cell that can improve pharmacokinetic and pharmacodynamic profi les of the drug. Th us the nanoparticles improve solubility, stability and bioavailability of various drugs. However, it is limited by toxic profi le. Th erefore, nanoparticle drug delivery system is highly challengeable for researchers to overcome toxicity. Th e application of nanoparticle in the fi eld of Medicine and Pharmaceuticals will be exposed more and more in near future. In our study, the antibacterial effi cacy of penicillin loaded chitosan nanoparticles was evaluated against selected bacterial strains namely Staphylococcus aureus, Streptococcus pyogenes, Bacillus subtilis, Escherichia coli and Klebsiella planticola of clinical origin. Th e study suggested that penicillin nanoparticles showed better antibiotic delivery system than conventional penicillin. However, the study is still under process in order to overcome lacunae that we experienced in our earlier studies.
