Ruchi Chawla
Indian Institute of Technology (Banaras Hindu University), India
Title: Hydrogels of solid lipid nanoparticles of curcumin
Biography
Biography: Ruchi Chawla
Abstract
Solid lipid nanoparticles of curcumin (C-SLNs) were prepared using stearic acid as lipid carrier by nano precipitation technique and characterized for their physio-chemical properties. SLNs were incorporated in hydro gels prepared from Carbopol®934 and the eff ect of method of incorporation of SLNs on the hydrogel properties was studied by Texture Analyzer. For the purpose of study, three types of hydro gels were prepared, i) Blank hydro gels B1, B2 and B3 containing respectively 0.5, 1.0 and 2.0 % w/v carpobol; ii) In-situ hydro gels Y1, Y2 and Y3 by adding carbopol (0.5, 1.0 and 2.0 % w/v) to fi xed volume of C-SLNs suspension and; iii) Enriched hydro gels by mixing C-SLNs and blank carbopol (1% w/v) hydrogel in the ratios 1:1 (D1) and 1:2 (D2). C-SLNs exhibited a mean particle size of 527.6 nm, poly dispersity of 0.383 and 82.73% entrapment efficiency. In-situ hydro gels exhibited a concentration (carbopol) dependent increase in fi rmness, consistency, cohesiveness and viscosity, however, presence of C-SLNs signifi cantly decreased (p<0.05) these values in comparison to blank hydro gels. Similar observations were made in enriched hydro gels. Also, a signifi cant difference (p<0.05) in hydrogel properties was observed between in-situ and enriched hydro gels. It indicates that SLNs have an eff ect on the swelling properties of Carbopol. Occlusive properties of in-situ hydrogels were better than enriched and blank hydro gels. In-situ hydro gels also exhibited uniform and extended release of curcumin, along with higher permeation characteristics. Better formulation characteristics of in-situ hydro gels might be because of homogenous deposition and gelling of carbopol around curcumin nanoparticles.
