Kanav Midha
Chitkara University, India
Title: Utility of modified locust bean gum for dissolution improvement of poorly soluble drug
Biography
Biography: Kanav Midha
Abstract
The present research was aimed at the enhancement of the dissolution rate of glimepiride by the solid dispersion technique using modifi ed locust bean gum. Th e locust bean gum was subjected to heat for modifi cation. Modifi ed solvent evaporation technique was used to prepare solid dispersions (in various drug: polymer ratios). Other mixtures were also prepared by physical mixing, co-grinding, and the kneading method. Various solid dispersions and other mixtures were evaluated for equilibrium solubility studies, content uniformity, FTIR, DSC, XRD, in vitro drug release, and in vivo pharmacodynamic studies. Maximum equilibrium solubility was observed in the solid dispersions SD3 (in a drug: polymer ratio of 1:6) and cogrinding mixture also showed equivalent solubility. Maximum dissolution rate was observed in the solid dispersion batch SD3 (i.e. 48% within 15 min) with maximum drug release aft er 2 h (89%). Th e co-grinding mixture also exhibited a signifi cant enhancement in the dissolution characteristics (45% in 15 min and 85% aft er 2h) among the other mixtures. FTIR studies indicated the absence of drug-polymer interaction in the solid dispersions, which was further supported by XRD studies. Minor shift s in the endothermic peaks of the DSC thermograms of SD3 and CGM indicated slight changes in drug crystallinity. Topological changes were seen in SEM images of SD3 and CGM. In vivo pharmacodynamic studies indicated an improved effi cacy of the optimized batch SD3 as compared to the pure drug (p≤0.05). Reduction in particle size, decreased crystallinity of drug with less viscosity and wetting ability of modifi ed locust bean lead to enhanced dissolution characteristics. Th e cogrinding mixture can be a good alternative to solid dispersions.
