Catarina Duarte
IBET, Portugal
Title: Application of high pressure technology for the development of intranasal delivery systems
Biography
Biography: Catarina Duarte
Abstract
Intranasal route have emerged in last years as an effective approach, even to brain delivery of drugs, as the brain and nose compartments are connected to each other via the olfactory/trigeminal systems. With this purposes, biocompatible drug delivery systems (DDS) including polymer-based or lipid-based systems have been studied and many formulations developed. In the present, new DDS such as multilayered microspheres and hybrid [polymer-lipid] dry forms are considered as alternative. This presentation will focus on the application of high pressure processes (e.g. supercritical fluid technology) as an alternative to conventional precipitation processes, and a precipitation technique that avoids completely the use of organic solvents will be presented. As exemples, the results on two hybrid delivery systems: [Gelucire 43/01™:PEG 4000] and [Gelucire 43/01™:GMO], produced by the PGSS® method(Particles from Gas Saturated Solutions) will be shown. Moreover, alginate-based hybrid aerogels (with low methoxyl pectin and κ-carrageenan), in the form of microparticles dried with supercritical CO2, will be presented as carriers for mucosal administration of drugs. These DDS were designed to allow the improved absorption of low molecular weight drugs or peptides after their administration though nasal mucosal tissue.
