Pharmaceutics & Novel Drug Delivery Systems

Biography

Biography: Behruz Barfi

Abstract

There are numerous challenges that the drug alone finds hard to overcome, such as the attack of enzymes, the poor permeability of some tissues, and the difficulty of access to the target once arriving at the destination cells, among others. As a consequence, the treatments usually involve the administration of relatively high doses of drug with the hope that a portion, although minor, goes to the right tissues or cells. The situation becomes worse in the case of new active substances obtained via biotechnological processes (peptides, enzymes, genes etc.), which have a complex structure and too deficient physicochemical and stability features to be able to reach/withstand the blood circulation. The ability to use nanotechnology to alter the characteristics of a drug to increase solubility, decrease degradation during circulation, and concentrate the drug at the desired site of action promises to increase efficacy while decreasing unwanted side effects. The development of an effective, versatile delivery option in nano-scale for the targeted delivery of therapeutic compounds has the potential to radically improve disease outcomes. The enormity of this opportunity has spurred much funding and research aimed toward the development of various nanoparticles for drug delivery systems. Herein, we will attempt to give insights into the currently developed drug delivery systems based on nano-sacales and present the resulting findings in an innovative manner, showing nanomaterials make a distinctive but endless world in the drug delivery systems.