Kuldeep H Ramteke
Modern College of Pharmacy, India
Title: Various potentials of isolated bael fruit gum in drotaverine hydrochloride tablets
Biography
Biography: Kuldeep H Ramteke
Abstract
Back ground: Gum constitute a major group of naturally occurring polymer, their abundance and low cost make them the preferred choice in foods and pharmaceuticals. Bael (Aegle Marmellose linn) fruits are edible, and reported in ancient system of medicines for their various activities.
Aim: The present research work was conducted to evaluate the various excipients potential of bale fruit gum (BFG) for solid dosage form. Material and Methods: BFG was isolated from partially ripe fruits of Bael. Identification and Standardization of BFG was carried out as per the stated procedures in the pharmacopoeia. Studies were conducted to support the physicochemical properties of gum. Solid state characterization of BFG was done by SEM, FTIR, DSC and XRD techniques. Different formulations were prepared to check the excipients profile of BFG like disintegrant, diluents, binder, carrier for solid dispersion, phosphorylated derivative and combination with other natural superdisintegrant and lyophilized derivative. Drotaverine Hydrochloride (DTV) was used as model drug for this experiment. Different tablet formulations were prepared and evaluated for physicochemical properties like appearance, average weight, hardness, thickness, disintegration, assay and dissolution. Prepared formulations were optimized by using the SeDeM diagram expert system to check the direct compression suitability of the blend.
Result: It was found that BFG possess good compressibility, flowability, low moisture content, neutral pH, amorphous nature and good water solubility. This made it suitable to be used as the release modulator in various dosage forms. It also possesses the binder and disintegrant property. When BFG was lyophilized, its surface characteristics were changed. Increase in pore size and ultimately the porosity and decrease in particle size proved its use as the superdisintegrant in immediate release tablets. Comparison of the BFG and Lyophilized BFG (LBFG) physicochemical properties shows that LBFG possess superior disintegrant potential compare to BFG for immediate Release tablet.
Conclusion: From the research work it was concluded that LBFG in concentration range of 10-12% shows superdisintegrant activity.