Vaginal Drug Delivery


The vagina has been studied as a favorable  site for the local and systemic delivery  of drugs and this route offers certain  advantages, such as avoidance of gut and  hepatic first pass metabolism, reduction  in gastrointestinal and hepatic side effects,  and local targeting of drugs to the  reproductive organs. Vaginally administered  agents and formulations are mainly  being developed to provide “dual prophylaxis”  for contraception and protection  against microbial infections including AIDS  and other sexually transmitted diseases  (STDs). Drug delivery technologies that  have been used for vaginal drug delivery  include the intravaginal ring (IVR) and  VagiSite bioadhesive technology.


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